- Home
- Organoid Culture Scientist
Organoid Culture Scientist
About the Company:
Ovelle is revolutionizing fertility treatment through human in vitro oogenesis—producing eggs from somatic cells. We have developed technology to create the cell types of the ovary from human induced pluripotent stem cells (iPSCs) by manipulating expression of transcription factors and RNA-binding proteins. Notably, we are the first company to produce meiotic oocyte-like cells from human iPSCs. This is an important step towards in vitro oogenesis because activating meiosis has been a key challenge in the field. We will incorporate these meiotic oocyte-like cells into ovarian organoids to create synthetic ovaries capable of producing eggs. By innovating egg production, we aim to make fertility treatments more accessible and affordable. If we are successful, it will mark a paradigm shift in treatments for infertility, and offer a new path to parenthood for millions of people around the world. Come help us build the exciting future we all want to live in.
About the Specific Role:
We seek an Organoid Culture Scientist to lead the development of advanced culture techniques for in vitro oogenesis, focusing on ovarian organoids. Your expertise will be instrumental in creating the optimal microenvironment for gamete development by leveraging tissue from mammalian models. This role offers a unique opportunity to apply your skills in a field with immense potential to impact global health and happiness.
How You Will Contribute:
Qualifications:
Ovelle is a research-first startup where scientists work together on only one deep and important problem: IVG. We operate like a fast, efficient academic lab without constraints. We’re committed to sharing our work with the scientific community and welcome collaborations with academic researchers.
We are well funded and have future funding commitments.
We encourage everyone to apply, as we value individuals who bring unique perspectives to our company. We welcome talented researchers; specific expertise in reproductive biology is not required.
Our benefits:
Ovelle is revolutionizing fertility treatment through human in vitro oogenesis—producing eggs from somatic cells. We have developed technology to create the cell types of the ovary from human induced pluripotent stem cells (iPSCs) by manipulating expression of transcription factors and RNA-binding proteins. Notably, we are the first company to produce meiotic oocyte-like cells from human iPSCs. This is an important step towards in vitro oogenesis because activating meiosis has been a key challenge in the field. We will incorporate these meiotic oocyte-like cells into ovarian organoids to create synthetic ovaries capable of producing eggs. By innovating egg production, we aim to make fertility treatments more accessible and affordable. If we are successful, it will mark a paradigm shift in treatments for infertility, and offer a new path to parenthood for millions of people around the world. Come help us build the exciting future we all want to live in.
About the Specific Role:
We seek an Organoid Culture Scientist to lead the development of advanced culture techniques for in vitro oogenesis, focusing on ovarian organoids. Your expertise will be instrumental in creating the optimal microenvironment for gamete development by leveraging tissue from mammalian models. This role offers a unique opportunity to apply your skills in a field with immense potential to impact global health and happiness.
How You Will Contribute:
- Establish and optimize culture conditions for long-term maintenance and growth of functional ovarian follicles
- Implement techniques for isolating and culturing granulosa cells and follicles from mammalian ovarian tissue
- Characterize the derived supporting cells using various molecular and functional assays
- Conduct co-culture experiments with germ cells to assess the supportive capacity of the derived cells
- Perform biology techniques such as FACS, immunofluorescence, and RNA-seq to evaluate cell identity and function
- Analyze hormone production and signaling pathways in cultured cells
- Collaborate on developing 3D culture systems that mimic the ovarian follicular environment
Qualifications:
- Strong analytical and problem-solving skills, with the ability to optimize complex multi-step protocols.
- Hands-on experience with mammalian tissue culture, including experience with 3D culture systems
- Proficiency in molecular biology techniques, including PCR, qPCR, RNA-seq, hormone assays, and signaling pathway analyses
- Experience with flow cytometry and cell sorting
- Experience with histology and immunofluorescence microscopy
- Experience with ovarian follicle culture, IVM, organoid culture, or microfluidics is a strong plus
- PhD in Biology, Biochemistry, or related field; DVM; or proven innovative work in the field
Ovelle is a research-first startup where scientists work together on only one deep and important problem: IVG. We operate like a fast, efficient academic lab without constraints. We’re committed to sharing our work with the scientific community and welcome collaborations with academic researchers.
We are well funded and have future funding commitments.
We encourage everyone to apply, as we value individuals who bring unique perspectives to our company. We welcome talented researchers; specific expertise in reproductive biology is not required.
Our benefits:
- 12.5 paid holidays
- PTO is three weeks annually, accruing at approximately 1.25 days per month
- Medical, Dental, and Vision
- Matching 401(k) plan
- Up to 12 weeks paid leave for new parents who are primary caregivers
- Tuition reimbursement for work-related continuing education
